Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model

Abstract Purpose We tend to evaluated a method for loading 6Mercaptopurine (6MP) on green synthesized hybrid chitosan gold nanoparticles (AuNPs) forming 6MP-AuNPs nanocomposite the first time in combinatorial chemo-photothermal therapy. Methods The AuNPs were using as reducing and capping agent. Different concentrations of 6MP mixed AuNPs. Cells incubated with loaded 48 h then exposed laser. Results have small sizes 18 ± 4 25 5 nm exhibit high stability Zeta potential 55.9 6.3 57 mV. irradiated Diode Pumped Solid State (DPSS) laser showed maximum inhibition cell viability reaching 63% at 1.25 µM. Conclusions A nanoparticle is powerful anti-cancer drug carrier well photothermal agent